The role of “disaggregation” in optical probe development

10.1039/c3cs60368gChemical Society Reviews4382402-241

Modeling and Performance Evaluation of Multistage Serial Manufacturing Systems with Rework Loops and Product Polymorphism

This paper studies multistage serial manufacturing systems with the integrated consideration of machine failures, process defects, multiple rework loops, etc. In particular, multiple rework loops and product polymorphism lead to a more complex conversion of internal material flows, and therefore it's difficult to model and analyse such manufacturing systems. A modular modeling method based on Generalized Stochastic Petri Nets (GSPN) is presented to characterize the material flows, it is capable of representing the processing differences resulting from product polymorphism comparing with traditional Markov model or Queuing network model. By analysing the model, the processing ratio of each workstation is inferred. Using 2M1B (two-machine and one-buffer) Markov cell model as the building blocks, which is obtained based on the GSPN models for their isomorphism, an overlapping decomposition method is then developed for evaluating the performance of the multistage serial systems with rework loops. Numerical experiments and a case study of a powertrain assembly line illustrate the efficiency of the proposed method

A Heuristic Approach to Solve an Industrial Scalability Problem

In recent years, the rapid change of market demand is increasing the need for scalability as a key characteristic of manufacturing systems. Scalability allows production capacity to be rapidly and cost-effectively reconfigured in different situation with different requirements and constraints. Our industrial partners are facing quarterly scalability problems involving a multi-unit and multi-product manufacturing system. In this paper, an original approach is presented to solve this kind of problems. Starting from the original manufacturing system configuration and process plan, a set of practical principles are introduced to seek for the feasible configurations; a GA is designed to search in the global solution space. A balancing objective function is defined and used to rank the proposed configurations. A real case study with 4-unit / 4-product situation demonstrates both the validity and efficiency of the proposed approach

Reliability Measurement for Multistate Manufacturing Systems with Failure Interaction

Reliability is one of the important factors for manufacturing system. Most researches assume that the failure is independent and the components only have two states, which will lead to inaccurate results. In this paper, a reliability model is proposed considering both failure interaction and multi-state property of the manufacturing system. Starting with a two-component system, a function of state probability under the impact of failure interaction is established after the analysis of failure interaction. Then the multi-component system is decomposed into several subsystems and the failure interaction coefficient is estimated in each subsystem with a Copula function and the Grey model method. Finally, the reliability model is realized with the performance generating function which is derived with the UGF technique and failure interaction coefficients. An example of a cylinder engine manufacturing system is studied, and the result is closer to the practical data

Production Line Layout Planning Based on Complexity Measurement

Mass customization production increases the difficulty of the production line layout planning. The material distribution process for variety of parts is very complex, which greatly increases the cost of material handling and logistics. In response to this problem, this paper presents an approach of production line layout planning based on complexity measurement. Firstly, by analyzing the influencing factors of equipment layout, the complexity model of production line is established by using information entropy theory. Then, the cost of the part logistics is derived considering different variety of parts. Furthermore, the function of optimization including two objectives of the lowest cost, and the least configuration complexity is built. Finally, the validity of the function is verified in a case study. The results show that the proposed approach may find the layout scheme with the lowest logistics cost and the least complexity. Optimized production line layout planning can effectively improve production efficiency and equipment utilization with lowest cost and complexity

Antimicrobial Resistance and Cytotoxicity of Citrobacter spp. in Maanshan Anhui Province, China

Objectives:Citrobacter spp. especially Citrobacter freundii, is frequently causing nosocomial infections, and increasingly becoming multi-drug resistant (MDR). In this study, we aimed to determine the genetic diversity and relationships of Citrobacter spp. from diarrheal patients and food sources, their antimicrobial resistance profiles and in vitro virulence properties.Methods: Sixty two Citrobacter isolates, including 13 C. freundii, 41 C. youngae and eight C. braakii isolates, were obtained from human diarrheal patients and food sources. Multilocus Sequence Typing (MLST) of seven housekeeping genes and antimicrobial susceptibility testing using the broth microdilution method according to CLSI recommendations were carried out. Adhesion and cytotoxicity to HEp-2 cells were performed. PCR and sequencing were used to identify blaCTX−M, blaSHV, blaTEM and qnr genes.Results: The 62 isolates were divided into 53 sequence types (STs) with all STs being novel, displaying high genetic diversity. ST39 was a predominant ST shared by 5 C. youngae strains isolated from four foods and a diarrheal patient. All isolates were resistant to cefoxitin, and sensitive to imipenem, meropenem and amikacin. The majority of Citrobacter isolates (61.3%) were MDR of three or more antibiotics out of the 22 antibiotics tested. Two C. freundii isolates each carried the blaTEM−1 gene and a variant of qnrB77. Three Citrobacter isolates each carried qnrS1 and aac(6')-Ib-cr genes. Seven isolates that showed strong cytotoxicity to HEp-2 cells were MDR.Conclusions:Citrobacter spp. from human and food sources are diverse with variation in virulence properties and antibiotic resistance profiles. Food may be an important source of Citrobacter species in transmission to humans. C. freundii and C. youngae are potential foodborne pathogens

A systematic review of studies on stress during the COVID-19 pandemic by visualizing their structure through COOC, VOS viewer, and Cite Space software

BackgroundThe COVID-19 epidemic generated different forms of stress. From this period, there has been a remarkable increase in the quantity of studies on stress conducted by scholars. However, few used bibliometric analyses to focus on overall trends in the field.PurposeThis study sought to understand the current status and trends in stress development during COVID-19, as well as the main research drives and themes in this field.Methods2719 publications from the Web of Science(WOS) core repository on stress during COVID-19 were analyzed by utilizing Co-Occurrence (COOC), VOS viewer, and Cite Space bibliometric software. The overall features of research on stress during COVID-19 were concluded by analyzing the quantity of publications, keywords, countries, and institutions.ResultsThe results indicated that the United States had the largest number of publications and collaborated closely with other countries with each other. University of Toronto was the most prolific institution worldwide. Visualization and analysis demonstrated that the influence of stress during COVID-19 on the work, life, mental and spiritual dimensions is a hot research topic. Among other things, the frequency of each keyword in research on stress during COVID-19 increased from 2021 to 2022, and the researchers expanded their scope and study population; the range of subjects included children, nurses, and college students, as well as studies focusing on different types of stress, and emphasizing the handling of stress.ConclusionOur findings reveal that the heat of stress research during COVID-19 has declined, and the main research forces come from the United States and China. Additionally, subsequent research should concern more on coping methods with stress, while using more quantitative and qualitative studies in the future

Urinary biomarkers associated with podocyte injury in lupus nephritis

The most prevalent and devastating form of organ damage in systemic lupus erythematosus (SLE) is lupus nephritis (LN). LN is characterized by glomerular injury, inflammation, cell proliferation, and necrosis, leading to podocyte injury and tubular epithelial cell damage. Assays for urine biomarkers have demonstrated significant promise in the early detection of LN, evaluation of disease activity, and tracking of reaction to therapy. This is because they are non-invasive, allow for frequent monitoring and easy self-collection, transport and storage. Podocyte injury is believed to be a essential factor in LN. The extent and type of podocyte injury could be connected to the severity of proteinuria, making podocyte-derived cellular debris and injury-related urinary proteins potential markers for the diagnosis and monitoring of LN. This article focuses on studies examining urinary biomarkers associated with podocyte injury in LN, offering fresh perspectives on the application of biomarkers in the early detection and management of LN